Lair1^tm1.1Amaz
Targeted Allele Detail

Summary

• Symbol: Lair1^tm1.1Amaz
• Name: leukocyte-associated Ig-like receptor 1; targeted mutation 1.1, Alexandra Mazharian
• MGI ID: MGI:7260248
• Synonyms: LAIR-1 KO
• Gene: Lair1 Location: Chr7:4006401-4066178 bp, - strand Genetic Position: Chr7, 2.31 cM
• Alliance: Lair1^tm1.1Amaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263672
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 and the proximal promoter were replaced with a F3-flanked positive puromycin selection cassette expressed under the control of an eukaryotic promoter and containing a polyadenylation signal. Flp1-mediated removal of the positive selection cassette results in the constitutive KO allele. (J:263672)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lair1 Mutation: 34 strains or lines available

References

• Original: J:263672 Smith CW, et al., Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets. Arterioscler Thromb Vasc Biol. 2017 May;37(5):823-835
• All: 6 reference(s)