Tspan6^tm1.1Pngr
Targeted Allele Detail

Summary

• Symbol: Tspan6^tm1.1Pngr
• Name: tetraspanin 6; targeted mutation 1.1, Josef M Penninger
• MGI ID: MGI:7260235
• Synonyms: Tspan6^fl
• Gene: Tspan6 Location: ChrX:132791817-132799178 bp, - strand Genetic Position: ChrX, 55.47 cM, cytoband E3
• Alliance: Tspan6^tm1.1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322705
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a second loxP site was inserted downstream of exon 6 via homologous recombination. Flp-mediated recombination removed the neo cassette leaving exons 2-6 floxed. (J:322705)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspan6 Mutation: 5 strains or lines available

References

• Original: J:322705 Humbert PO, et al., TSPAN6 is a suppressor of Ras-driven cancer. Oncogene. 2022 Apr;41(14):2095-2105
• All: 1 reference(s)