Vipr2^em1Zhoux
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vipr2^em1Zhoux
• Name: vasoactive intestinal peptide receptor 2; endonuclease-mediated mutation 1, Xiangtian Zhou
• MGI ID: MGI:7260127
• Synonyms: Vipr2-KO
• Gene: Vipr2 Location: Chr12:116041346-116109881 bp, + strand Genetic Position: Chr12, 62.59 cM, cytoband F2
• Alliance: Vipr2^em1Zhoux page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using the CRISPR/Cas9-mediated genome editing, Exon 2 of Vipr2 was deleted leading to a new stop codon that produced a 54 amino acid truncated protein. (J:322356)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vipr2 Mutation: 30 strains or lines available

References

• Original: J:322356 Zhao F, et al., Dysfunction of VIPR2 leads to myopia in humans and mice. J Med Genet. 2022 Jan;59(1):88-100
• All: 1 reference(s)