Tln1^em1Mgin
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tln1^em1Mgin
• Name: talin 1; endonuclease-mediated mutation 1, Mark H Ginsberg
• MGI ID: MGI:7260105
• Synonyms: Tln1^R35E
• Gene: Tln1 Location: Chr4:43531513-43562583 bp, - strand Genetic Position: Chr4, 23.05 cM
• Alliance: Tln1^em1Mgin page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL)F2

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/Cas9 technology, nucleotides in exon 1 were substituted to result in the amino acid substitutions of Arg 35 to Glu (R35E). Arg 35 forms crucial salt bridges with an acidic patch on Rap1b. (J:322715)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tln1 Mutation: 147 strains or lines available

References

• Original: J:322715 Lagarrigue F, et al., Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018 Sep 25;2(18):2358-2368
• All: 2 reference(s)