Cyld^tm1.1Ozg
Targeted Allele Detail

Summary

• Symbol: Cyld^tm1.1Ozg
• Name: CYLD lysine 63 deubiquitinase; targeted mutation 1.1, Ozgene
• MGI ID: MGI:7259786
• Synonyms: Cyld^D215A
• Gene: Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
• Alliance: Cyld^tm1.1Ozg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Aspartic acid codon 215 (GAT) in exon 2 was mutated to alanine (GCT) (p.D215A). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 1 was removed through subsequent cre-mediated recombination. (J:281456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyld Mutation: 45 strains or lines available

References

• Original: J:281456 Newton K, et al., Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019 Oct;574(7778):428-431
• All: 1 reference(s)