Fadd^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Fadd^tm1.1Tac
• Name: Fas associated via death domain; targeted mutation 1.1, Taconic
• MGI ID: MGI:7259785
• Synonyms: Fadd^-
• Gene: Fadd Location: Chr7:144132060-144136178 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fadd^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted upstream of exon 1 and into intron 1. Exon 1 was deleted through subsequent cre-mediated recombination (chr7:144,581,754-144,584,070 (GRCm38.p4)) (J:281456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fadd Mutation: 18 strains or lines available

References

• Original: J:281456 Newton K, et al., Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019 Oct;574(7778):428-431
• All: 1 reference(s)