Casp8^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Casp8^tm1.1Tac
• Name: caspase 8; targeted mutation 1.1, Taconic
• MGI ID: MGI:7258499
• Synonyms: Casp8^C362A
• Gene: Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Cysteine codon 362 (TGC) in exon 9 was mutated to alanine (GCA) (p.C362A). The FRT site flanked neomycin selection gene cassette that was inserted into intron 8 was removed through subsequent flp-mediated recombination. (J:281456)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 45 strains or lines available

References

• Original: J:281456 Newton K, et al., Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019 Oct;574(7778):428-431
• All: 3 reference(s)