Casp8^em1Jhan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Casp8^em1Jhan
• Name: caspase 8; endonuclease-mediated mutation 1, Jiahuai Han
• MGI ID: MGI:7258403
• Synonyms: Casp8^-
• Gene: Casp8 Location: Chr1:58834533-58886662 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^em1Jhan page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: A 142 bp deletion (ACCATCGAGGATGCCCAGAAGCTATTTC..TGCTGGTCAACTTCCTAGACTGCAACCGAGA) knockout allele was created using sgRNAs (targeting TCGAGGATGCCCAGAAGCT and TTCCTAGACTGCAACCGAG) with CRISPR/Cas9 technology. (J:309361)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 42 strains or lines available

References

• Original: J:309361 Zhang Y, et al., A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5. PLoS Biol. 2021 Aug;19(8):e3001304
• All: 1 reference(s)