Sarm1^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Sarm1^tm1.1Smoc
• Name: sterile alpha and HEAT/Armadillo motif containing 1; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:7256930
• Gene: Sarm1 Location: Chr11:78363156-78388580 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Sarm1^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322144
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the first exon and an FRT flanked neo cassette and loxP site were inserted downstream of the second exon via homologous recombination. Flp mediated recombination removed the neo cassette. (J:322144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sarm1 Mutation: 27 strains or lines available

References

• Original: J:322144 Liu H, et al., SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-kappaB signaling. Theranostics. 2021;11(9):4187-4206
• All: 4 reference(s)