Tnfrsf1a^{tm1.1(TNFRSF1A)Ulme}
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1a^{tm1.1(TNFRSF1A)Ulme}
• Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1.1, Ulrich L M Eisel
• MGI ID: MGI:7256732
• Synonyms: hu/mTNFR1-k/i
• Gene: Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Tnfrsf1a^{tm1.1(TNFRSF1A)Ulme} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238801
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The mouse genomic region between 125306866-12531062 including exons 2 - 6 was replaced with the homologous human region (Chr12:6330763-6332522). In addition a floxed pgk-neo cassette was inserted between exons 5 and 6. Cre mediated recombination then removed the neo cassette. (J:238801)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1a Mutation: 51 strains or lines available

References

• Original: J:238801 Dong Y, et al., Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12304-12309
• All: 4 reference(s)