Ripk3^tm1.1Vmd
Targeted Allele Detail

Summary

• Symbol: Ripk3^tm1.1Vmd
• Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1.1, Vishva M Dixit
• MGI ID: MGI:7256694
• Synonyms: Ripk3^-
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^tm1.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209137
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence fragment encompassing exons 1 through 3 was replaced with a loxP site flanked neomycin resistance gene cassette. Subsequent Cre-mediated recombination deleted the neo cassette. (J:87683, J:209137)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 31 strains or lines available

References

• Original: J:209137 Newton K, et al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
• All: 18 reference(s)