Stx4a^tm1.1Kaws
Targeted Allele Detail

Summary

• Symbol: Stx4a^tm1.1Kaws
• Name: syntaxin 4A (placental); targeted mutation 1.1, Shinji Kawai
• MGI ID: MGI:7256630
• Synonyms: Stx4a^flox
• Gene: Stx4a Location: Chr7:127439832-127450160 bp, + strand Genetic Position: Chr7, 69.77 cM, cytoband F4
• Alliance: Stx4a^tm1.1Kaws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316296
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 1 and a loxP site was inserted downstream of exon 1 via homologous recombination.Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:316296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx4a Mutation: 20 strains or lines available

References

• Original: J:316296 Kawai S, et al., Syntaxin 4a Regulates Matrix Vesicle-Mediated Bone Matrix Production by Osteoblasts. J Bone Miner Res. 2017 Mar;32(3):440-448
• All: 1 reference(s)