Camk2b^tm4Yelg
Targeted Allele Detail

Summary

• Symbol: Camk2b^tm4Yelg
• Name: calcium/calmodulin-dependent protein kinase II, beta; targeted mutation 4, Ype Elgersma
• MGI ID: MGI:7254987
• Synonyms: Camk2b^T287A
• Gene: Camk2b Location: Chr11:5919644-6016362 bp, - strand Genetic Position: Chr11, 3.89 cM
• Alliance: Camk2b^tm4Yelg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251803
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: A cassette containing a neomycin resistance gene, flanked by LoxP sites, was inserted downstream of exon 11. The T287A mutation was introduced by site directed mutagenesis, thereby also introducing a TspRI restriction site. The neomycin cassette was subsequently deleted of the targeted ES clones by transient transfection with a flp recombinase. (J:251803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2b Mutation: 93 strains or lines available

References

• Original: J:251803 Kool MJ, et al., The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. Sci Rep. 2016 May 31;6:26989
• All: 2 reference(s)