Camk2b^tm3.1Yelg
Targeted Allele Detail

Summary

• Symbol: Camk2b^tm3.1Yelg
• Name: calcium/calmodulin-dependent protein kinase II, beta; targeted mutation 3.1, Ype Elgersma
• MGI ID: MGI:7254984
• Gene: Camk2b Location: Chr11:5919644-6016362 bp, - strand Genetic Position: Chr11, 3.89 cM
• Alliance: Camk2b^tm3.1Yelg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251803
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing a neomycin resistance gene, flanked by FRT sites, was inserted upstream of exon 2. LoxP sites were introduced upstream of this cassette and downstream of exon2. The neomycin cassette was subsequently deleted of the targeted ES clones by transient transfection with a flp recombinase. Cre-mediated recombination removed exon 2. (J:251803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2b Mutation: 93 strains or lines available

References

• Original: J:251803 Kool MJ, et al., The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. Sci Rep. 2016 May 31;6:26989
• All: 3 reference(s)