Ephb4^em1Pdk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ephb4^em1Pdk
• Name: Eph receptor B4; endonuclease-mediated mutation 1, Philip King
• MGI ID: MGI:6888278
• Synonyms: EPHB4 2YP
• Gene: Ephb4 Location: Chr5:137348371-137372784 bp, + strand Genetic Position: Chr5, 76.38 cM
• Alliance: Ephb4^em1Pdk page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL/J)F1/J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting inserted the mutations for the amino acid substitutions Y590F/P593G/Y596F/P599G (Ephb4 2YP). (J:321520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephb4 Mutation: 44 strains or lines available

References

• Original: J:321520 Chen D, et al., Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells. JCI Insight. 2022 Feb 22;7(4):e156928
• All: 2 reference(s)