Pgr^em2Lvntu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pgr^em2Lvntu
• Name: progesterone receptor; endonuclease-mediated mutation 2, Valerie Lin
• MGI ID: MGI:6888218
• Synonyms: PgR_AF1_FFF
• Gene: Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Pgr^em2Lvntu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 endonuclease-mediated genome editing is used to create an amino acid substitutions at positions 461 (lysine to phenylalanine, K461F, AAA to TTT), 478 (lysine to phenylalanine, K478F, AAG to TTT), and 489 (arginine to phenylalanine, R489F, CGG to TTC) in the activation function 1 domain.. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pgr Mutation: 73 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)