Pgr^em1Lvntu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pgr^em1Lvntu
• Name: progesterone receptor; endonuclease-mediated mutation 1, Valerie Lin
• MGI ID: MGI:6888212
• Synonyms: PgR_AF1_QQQ
• Gene: Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Pgr^em1Lvntu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 endonuclease-mediated genome editing is used to create amino acid substitutions at positions 461 (lysine to glutamine, K461Q, AAA to CAA), 478 (lysine to glutamine, K478Q, AAG to CAG), and 489 (arginine to glutamine, R489Q, CGG to CAG) located in the activation function 1 (AF1) domain. (J:326815)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pgr Mutation: 73 strains or lines available

References

• Original: J:326815 Lee SH, et al., Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy. Sci Rep. 2022 Jul 19;12(1):12286
• All: 2 reference(s)