Msh2^tm2Htr
Targeted Allele Detail

Summary

• Symbol: Msh2^tm2Htr
• Name: mutS homolog 2; targeted mutation 2, Hein Te Riele
• MGI ID: MGI:6887969
• Synonyms: Msh2^E876Xs, Msh2^Ex, Msh2^EXs
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm2Htr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The E876 codon of the mouse Msh2 gene was substituted for a TGA stop codon truncating the MSH2 C-terminal 60 amino acids. (J:320945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

References

• Original: J:320945 Wielders E, et al., Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome. Fam Cancer. 2017 Apr;16(2):221-229
• All: 1 reference(s)