Ccl28^em1Zhigx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccl28^em1Zhigx
• Name: C-C motif chemokine ligand 28; endonuclease-mediated mutation 1, Zhigao Xu
• MGI ID: MGI:6887956
• Synonyms: Ccl28^-
• Gene: Ccl28 Location: Chr13:120085355-120115895 bp, + strand Genetic Position: Chr13, Syntenic
• Alliance: Ccl28^em1Zhigx page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9-mediated genome editing, 53 bp in the exon 2 of the Ccl28 gene was deleted causing a reading frame shift and the early translational termination. Quantitative real-time PCR (qRT-PCR) analysis of CCL28 mRNA derived from lung, colon, and salivary glands confirms the absence of mRNA in the homozygous mice. (J:321185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccl28 Mutation: 8 strains or lines available

References

• Original: J:321185 Lin D, et al., Dispensable role of CCL28 in Kras-mutated non-small cell lung cancer mouse models. Acta Biochim Biophys Sin (Shanghai). 2020 Jun 20;52(6):691-694
• All: 1 reference(s)