Gpr4^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpr4^em1Gpt
• Name: G protein-coupled receptor 4; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6887882
• Synonyms: Gpr4^-, Gpr4^em1Cd
• Gene: Gpr4 Location: Chr7:18946463-18958099 bp, + strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gpr4^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Using the CRISPR/Cas9 system, the entire coding region (exon2) of the Gpr4 gene was deleted. (J:321623)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr4 Mutation: 26 strains or lines available

References

• Original: J:321623 Li R, et al., The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling. Cell Death Dis. 2022 Feb 14;13(2):152
• All: 1 reference(s)