Tjp1^tm1.1Pmoh
Targeted Allele Detail

Summary

• Symbol: Tjp1^tm1.1Pmoh
• Name: tight junction protein 1; targeted mutation 1.1, Peter J Mohler
• MGI ID: MGI:6887861
• Synonyms: ZO-1^-
• Gene: Tjp1 Location: Chr7:64945913-65177529 bp, - strand Genetic Position: Chr7, 35.02 cM
• Alliance: Tjp1^tm1.1Pmoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321611
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: The FRT flanked LacZ-neo-cassette and a loxP replaced a portion of the intron between exons 2 and 3 of the Tjp1 gene. A second loxP site was inserted into the intron between exon 3 and 4, leaving the exon 3 flanked by a pair of loxP. The allele is a hypomorph of ZO-1 isoform resulting in a significant reduction in Tjp1 mRNA levels in the heterozygous mice. (J:321611)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tjp1 Mutation: 69 strains or lines available

References

• Original: J:321611 El Refaey M, et al., Altered Expression of Zonula occludens-1 Affects Cardiac Na(+) Channels and Increases Susceptibility to Ventricular Arrhythmias. Cells. 2022 Feb 14;11(4)
• All: 1 reference(s)