Pip5k1c^tm1.1Gxo
Targeted Allele Detail

Summary

• Symbol: Pip5k1c^tm1.1Gxo
• Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; targeted mutation 1.1, Guozhi Xiao
• MGI ID: MGI:6887745
• Synonyms: Pip5k1c^fl
• Gene: Pip5k1c Location: Chr10:81128797-81155807 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Pip5k1c^tm1.1Gxo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321599
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The exon two of the mouse Pip5k1c gene is flanked by two loxP sites and followed by a FRT site-flanked neomycin cassette before exon 3. Flp-mediated recombination removed the neomycin resistance cassette. (J:321599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pip5k1c Mutation: 42 strains or lines available

References

• Original: J:321599 Yan Q, et al., Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling. J Biol Chem. 2022 Jan 25;298(3):101639
• All: 1 reference(s)