Crebrf^em1Rbr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crebrf^em1Rbr
• Name: CREB3 regulatory factor; endonuclease-mediated mutation 1, Robert Brink
• MGI ID: MGI:6887644
• Synonyms: Crebrf R458Q
• Gene: Crebrf Location: Chr17:26934624-26995609 bp, + strand Genetic Position: Chr17, 13.5 cM, cytoband B1
• Alliance: Crebrf^em1Rbr page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• CRISPR/Cas9 technology generated an arginine to glutamine substitution at amino acid 458 (R458Q). (J:321583)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crebrf Mutation: 42 strains or lines available

References

• Original: J:321583 Metcalfe LK, et al., Limited Metabolic Effect of the CREBRF(R457Q) Obesity Variant in Mice. Cells. 2022 Jan 31;11(3)
• All: 1 reference(s)