Trpv1^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Trpv1^tm1.1Cya
• Name: transient receptor potential cation channel, subfamily V, member 1; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6886084
• Synonyms: Trpv1^G564S, Trpv1^tm1.1Cgen
• Gene: Trpv1 Location: Chr11:73125118-73152068 bp, + strand Genetic Position: Chr11, 45.25 cM, cytoband B3
• Alliance: Trpv1^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278209
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutation: Single point mutation
• Mutation details: A G>A mutation (c.1690G>A) was engineered to change glycine codon 564 in exon 11 to a serine codon (p.G564S) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 12. The neo cassette was removed through subsequent cre-mediated recombination. The mutation is a gain-of-function mutation leading to a severe reduction in capsaicin and noxious heat sensitivity. (J:278209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv1 Mutation: 65 strains or lines available

References

• Original: J:278209 Duo L, et al., TRPV1 gain-of-function mutation impairs pain and itch sensations in mice. Mol Pain. 2018 Jan-Dec;14:1744806918762031
• All: 2 reference(s)