Gata1^tm1.1Schro
Targeted Allele Detail

Summary

• Symbol: Gata1^tm1.1Schro
• Name: GATA binding protein 1; targeted mutation 1.1, Timm Schroeder
• MGI ID: MGI:6885831
• Synonyms: Gata1-mCherry, GATA1^mCherry
• Gene: Gata1 Location: ChrX:7825504-7842844 bp, - strand Genetic Position: ChrX, 3.59 cM, cytoband A2
• Alliance: Gata1^tm1.1Schro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236311
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector inserted a short linker followed by the coding sequence for mCherry and an FRT (FLP recognition target)-flanked phospho-glycerate kinase (PGK) promoter-driven neomycin (neo) resistance gene after the last codon of Gata1 gene (skipping the endogenous stop-codon). The FRT-flanked neo selection cassette was deleted in vivo by a Flpe deleter strain by recombinase-mediated excision. (J:236311)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata1 Mutation: 46 strains or lines available

References

• Original: J:236311 Hoppe PS, et al., Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios. Nature. 2016 Jul 13;535(7611):299-302
• All: 3 reference(s)