Tmem120a^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Tmem120a^tm1.1Tac
• Name: transmembrane protein 120A; targeted mutation 1.1, Taconic
• MGI ID: MGI:6885826
• Synonyms: Tmem120a^fl
• Gene: Tmem120a Location: Chr5:135764344-135773026 bp, - strand Genetic Position: Chr5, 75.38 cM
• Alliance: Tmem120a^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321295
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 and 3 were flanked by loxP sites. An FRT-flanked puromycin selection cassette was inserted dodwnsteam of exon 3 before the second loxP site and was removed via flp-mediated recombination. (J:321295)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem120a Mutation: 19 strains or lines available

References

• Original: J:321295 Czapiewski R, et al., Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy. Nat Commun. 2022 Jan 13;13(1):321
• All: 1 reference(s)