Prss3b^tm3.1Satom
Targeted Allele Detail

Summary

• Symbol: Prss3b^tm3.1Satom
• Name: serine protease 3B; targeted mutation 3.1, Miklos Sahin-Toth
• MGI ID: MGI:6885796
• Synonyms: T7K24R
• Gene: Prss3b Location: Chr6:41007202-41012443 bp, - strand Genetic Position: Chr6, 19.1 cM
• Alliance: Prss3b^tm3.1Satom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320409
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: To mimic a mutation associated with hereditary pancreatitis in human (p.K23R), lysine codon 24 (AAA) in exon 2 was mutated to an arginine codon (AGA) (c.71A>G, p.K24R). A loxP site flanked neomycin resistance gene cassette was inserted into intron 1 and removed through subsequent cre-mediated recombination. (J:320409)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss3b Mutation: 24 strains or lines available

References

• Original: J:320409 Jancso Z, et al., Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice. Gastroenterology. 2020 Mar;158(4):1083-1094
• All: 1 reference(s)