Traf3ip2^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Traf3ip2^tm1.1Geno
• Name: TRAF3 interacting protein 2; targeted mutation 1.1, Genoway
• MGI ID: MGI:6883632
• Synonyms: Act1 L286G
• Gene: Traf3ip2 Location: Chr10:39488930-39531303 bp, + strand Genetic Position: Chr10, 20.86 cM
• Alliance: Traf3ip2^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320994
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct inserted a mutation in a floxed exon 3 that results in a leucine to glycine amino acid substitution at position 286 (L286G). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:320994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf3ip2 Mutation: 41 strains or lines available

References

• Original: J:320994 Lipovsky A, et al., ACT1 Is Required for Murine IL-23-Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity. J Invest Dermatol. 2021 Jul;141(7):1772-1779.e6
• All: 1 reference(s)