Slc31a1^em1Bjme
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc31a1^em1Bjme
• Name: solute carrier family 31, member 1; endonuclease-mediated mutation 1, Bradley J Merrill
• MGI ID: MGI:6883631
• Synonyms: mCtr1(C187A), mCtr1^KI
• Gene: Slc31a1 Location: Chr4:62278964-62310006 bp, + strand Genetic Position: Chr4, 33.11 cM, cytoband C1-C2
• Alliance: Slc31a1^em1Bjme page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a cysteine to alanine substitution at amino acid 195 [previously residue187 (C187A)] resulting in a Cys195-oxidation-defective redox-dead Slc31a1 mutant mice. This corresponds to the human C189A. (J:321043)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc31a1 Mutation: 41 strains or lines available

References

• Original: J:321043 Das A, et al., Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. Nat Cell Biol. 2022 Jan;24(1):35-50
• All: 1 reference(s)