Kdm2b^em1Zhanz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kdm2b^em1Zhanz
• Name: lysine (K)-specific demethylase 2B; endonuclease-mediated mutation 1, Zhenzhen Zhan
• MGI ID: MGI:6883557
• Synonyms: Kdm2b^-
• Gene: Kdm2b Location: Chr5:123008727-123127333 bp, - strand Genetic Position: Chr5, 62.63 cM, cytoband F
• Alliance: Kdm2b^em1Zhanz page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using the CRISPR-Cas9 system, seventeen bases of the Jmjc domain responsible for its demethylase activity were deleted from the Kdm2b gene resulting in a frameshift mutation. (J:320919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm2b Mutation: 220 strains or lines available

References

• Original: J:320919 Zhou Q, et al., KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling. Cell Mol Immunol. 2020 Aug;17(8):834-842
• All: 1 reference(s)