Wnt1^tm1.1Pg
Targeted Allele Detail

Summary

• Symbol: Wnt1^tm1.1Pg
• Name: wingless-type MMTV integration site family, member 1; targeted mutation 1.1, PolyGene AG
• MGI ID: MGI:6881739
• Synonyms: Wnt1^G177C
• Gene: Wnt1 Location: Chr15:98687738-98691711 bp, + strand Genetic Position: Chr15, 54.65 cM, cytoband F1-F3
• Alliance: Wnt1^tm1.1Pg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320847
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct inserted the point mutation G to T at c.529 generating the amino acid substitution of glycine with cysteine at position 177 (G177C). An additional silent c.534G to A mutation was introduced to generate a new restriction site. Flp-mediated recombination removed the selection cassette. (J:320847)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt1 Mutation: 29 strains or lines available

References

• Original: J:320847 Vollersen N, et al., The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV. Bone Res. 2021;9(1):48
• All: 1 reference(s)