Fbn1^tm1.1Lysa
Targeted Allele Detail

Summary

• Symbol: Fbn1^tm1.1Lysa
• Name: fibrillin 1; targeted mutation 1.2, Lynn Y Sakai
• MGI ID: MGI:6881736
• Synonyms: Fbn1^floxed
• Gene: Fbn1 Location: Chr2:125142514-125348417 bp, - strand Genetic Position: Chr2, 61.38 cM, cytoband F
• Alliance: Fbn1^tm1.1Lysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165897
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A lox66 site was inserted upstream of exon 33. The following vector was inserted into intron 34 (5' through 3'): eGFP, exon 33 splice acceptor site, lox77 site, and FRT flanked neo cassette. Flp mediated recombination removed the neo cassette. Cre-mediated recombination will invert the region between lox66 and lox77, bringing eGFP into frame after exon 32. (J:165897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbn1 Mutation: 174 strains or lines available

References

• Original: J:165897 Charbonneau NL, et al., In vivo studies of mutant fibrillin-1 microfibrils. J Biol Chem. 2010 Aug 6;285(32):24943-55
• All: 2 reference(s)