Dmkn^tm1.1Hase
Targeted Allele Detail

Summary

• Symbol: Dmkn^tm1.1Hase
• Name: dermokine; targeted mutation 1.1, Minoru Hasegawa
• MGI ID: MGI:6877108
• Synonyms: DMKN-beta gamma^-
• Gene: Dmkn Location: Chr7:30463181-30480488 bp, + strand Genetic Position: Chr7, 19.24 cM, cytoband A3
• Alliance: Dmkn^tm1.1Hase page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297240
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: By homologous recombination in ES cells, exon 1 of the Dmkn gene was flanked by loxP sites. Frt flanked neo cassette was also inserted in between two loxP sites upstream of exon 1. CAG promoter-driven Cre-mediated loxP recombination deleted exon 1 of the gene which is shared by both beta and gamma isoforms. (J:297240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmkn Mutation: 25 strains or lines available

References

• Original: J:297240 Utsunomiya A, et al., Homeostatic Function of Dermokine in the Skin Barrier and Inflammation. J Invest Dermatol. 2020 Apr;140(4):838-849.e9
• All: 1 reference(s)