Runx2^tm1.1Tok
Targeted Allele Detail

Summary

• Symbol: Runx2^tm1.1Tok
• Name: runt related transcription factor 2; targeted mutation 1.1, Toshihisa Komori
• MGI ID: MGI:6874594
• Synonyms: Runx2^fl
• Gene: Runx2 Location: Chr17:44806873-45125518 bp, - strand Genetic Position: Chr17, 21.33 cM
• Alliance: Runx2^tm1.1Tok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299239
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 (previously exon 1), encoding the N-terminal region and part of the Runt domain, was flanked by loxP sites. An FRT-flanked neomycin resistance gene was inserted in between exon 3 and the second loxP site and was removed via flp-mediated recombination. (J:299239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx2 Mutation: 44 strains or lines available

References

• Original: J:299239 Qin X, et al., Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genet. 2020 Nov;16(11):e1009169
• All: 4 reference(s)