Lifr^tm1.1Maik
Targeted Allele Detail

Summary

• Symbol: Lifr^tm1.1Maik
• Name: LIF receptor alpha; targeted mutation 1.1, Masahito Ikawa
• MGI ID: MGI:6871044
• Synonyms: Lifr^loxP
• Gene: Lifr Location: Chr15:7120095-7226970 bp, + strand Genetic Position: Chr15, 3.46 cM
• Alliance: Lifr^tm1.1Maik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:318712
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct obtained from Helmholtz Zentrum Muenchen GmbH inserted upstream of exon 5 an FRT site, splice acceptor, IRES sequence, lacZ reporter gene, polyadenylation sequence, loxP site, neomycin resistance cassette, FRT site, and loxP site. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the reporter gene and selection cassette. (J:318712)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lifr Mutation: 59 strains or lines available

References

• Original: J:318712 Fukui Y, et al., Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment. Endocrinology. 2021 Nov 1;162(11)
• All: 1 reference(s)