Cd3e^{em1(CD3E)Amgn}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd3e^{em1(CD3E)Amgn}
• Name: CD3 antigen, epsilon polypeptide; endonuclease-mediated mutation 1, Amgn
• MGI ID: MGI:6871031
• Synonyms: huCD3e
• Gene: Cd3e Location: Chr9:44910038-44920925 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Cd3e^{em1(CD3E)Amgn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:318716
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: CRISPR-targeting produced a fusion between the endogenous gene and the human sequence within the BiTE binding region (Q22-T48). A floxed neomycin resistance cassette was inserted downstream of exon 2. (J:318716)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd3e Mutation: 21 strains or lines available

References

• Original: J:318716 Belmontes B, et al., Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors. Sci Transl Med. 2021 Aug 25;13(608)
• All: 1 reference(s)