Rr45^tm2.1Tshir
Targeted Allele Detail

Summary

• Symbol: Rr45^tm2.1Tshir
• Name: regulatory region 45; targeted mutation 2.1, Toshihiko Shiroishi
• MGI ID: MGI:6870536
• Synonyms: deltaMFCS4, MFCS4^-
• Gene: Rr45 Location: Chr5:29392493-29393491 bp Genetic Position: Chr5, Syntenic
• Alliance: Rr45^tm2.1Tshir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320178
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene cassette replaced 1 kb including the MFCS4 (mammals-fish conserved sequence 4) enhancer of Shh located within intron 8 of Rnf32. This allele was created in ES cells that already carry the Rr114^tm1.1Tshir allele (deletion of enhancer MRCS1). (J:320178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr45 Mutation: 2 strains or lines available

References

• Original: J:320178 Sagai T, et al., SHH signaling directed by two oral epithelium-specific enhancers controls tooth and oral development. Sci Rep. 2017 Oct 11;7(1):13004
• All: 1 reference(s)