Srf^tm1.1Sor
Targeted Allele Detail

Summary

• Symbol: Srf^tm1.1Sor
• Name: serum response factor; targeted mutation 1.1, Philippe Sorian
• MGI ID: MGI:6867804
• Synonyms: Srf^aI
• Gene: Srf Location: Chr17:46859255-46867101 bp, - strand Genetic Position: Chr17, 22.9 cM
• Alliance: Srf^tm1.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319847
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Epitope tag, Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct inserted four knock-in point mutations in the alpha I helix of the DNA-binding domain. A triple FLAG tag was introduced at the N-terminus. Cre-mediated recombination removed the selection cassette. (J:319847)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Srf Mutation: 25 strains or lines available

References

• Original: J:319847 Dinsmore CJ, et al., Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors. Elife. 2022 Jan 19;11:e75106
• All: 1 reference(s)