Srr^tm1.1Fede
Targeted Allele Detail

Summary

• Symbol: Srr^tm1.1Fede
• Name: serine racemase; targeted mutation 1.1, Frank Edenhofer
• MGI ID: MGI:6867022
• Gene: Srr Location: Chr11:74797185-74816774 bp, - strand Genetic Position: Chr11, 45.76 cM, cytoband B4
• Alliance: Srr^tm1.1Fede page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319913
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A fragment from serine racemase (Srr) BAC RP23-174M12 (RZPD) containing exons 39 was used as a targeting vector to insert two loxP sites flanking exons 26 followed by a 1.6-kb FRT-PGK-gb2-neo-FRT loxP fragment. After FLP recombination, the FRT-PGK-gb2-neo-FRT cassette is excised, leaving a single FRT and loxP sites. (J:319913)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srr Mutation: 35 strains or lines available

References

• Original: J:319913 Patsch C, et al., Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells. Stem Cells. 2010 May;28(5):894-902
• All: 1 reference(s)