Cnp^{tm1.1(icre)Htak}
Targeted Allele Detail

Summary

• Symbol: Cnp^{tm1.1(icre)Htak}
• Name: 2',3'-cyclic nucleotide 3' phosphodiesterase; targeted mutation 1.1, Hirohide Takebayashi
• MGI ID: MGI:6865676
• Synonyms: Cnp^iCre
• Gene: Cnp Location: Chr11:100465765-100472565 bp, + strand Genetic Position: Chr11, 63.47 cM
• Alliance: Cnp^{tm1.1(icre)Htak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319558
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Cnp^{tm1.1(icre)Htak} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cnp (MGI:88437)

• Mutation details: The targeting construct inserted an improved cre recombinase gene (icre) at the translation initiation site in exon 2. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the recombinase gene. (J:319558)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cnp (mouse) Summary of all recombinase alleles driven by Cnp. Alliance mouse Cnp gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnp Mutation: 26 strains or lines available

References

• Original: J:319558 Bizen N, et al., Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ. 2022
• All: 1 reference(s)