Cxcl12^tm1.1Gle
Targeted Allele Detail

Summary

• Symbol: Cxcl12^tm1.1Gle
• Name: C-X-C motif chemokine ligand 12; targeted mutation 1.1, Gustavo Leone
• MGI ID: MGI:6864530
• Synonyms: Cxcl12^f
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^tm1.1Gle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314996
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT flanked neo cassette was inserted downstream of exon 2. FLPe-mediated recombination removed the neo cassette and left exon 1-2 floxed. (J:314996)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 24 strains or lines available

References

• Original: J:314996 Ahirwar DK, et al., Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation. Oncogene. 2018 Aug;37(32):4428-4442
• All: 1 reference(s)