Ostn^tm1.1Jhei
Targeted Allele Detail

Summary

• Symbol: Ostn^tm1.1Jhei
• Name: osteocrin; targeted mutation 1.1, Joerg Heineke
• MGI ID: MGI:6864469
• Synonyms: Ostn^fl
• Gene: Ostn Location: Chr16:27126239-27169962 bp, + strand Genetic Position: Chr16, 18.88 cM
• Alliance: Ostn^tm1.1Jhei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319555
• Parent Cell Line: iTL BF1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted about 83 bp upstream of exon 3 and a loxP site and an FRT-flanked neomycin selection cassette was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette, leaving exon 3 floxed. (J:319555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ostn Mutation: 13 strains or lines available

References

• Original: J:319555 Szaroszyk M, et al., Skeletal muscle derived Musclin protects the heart during pathological overload. Nat Commun. 2022 Jan 10;13(1):149
• All: 1 reference(s)