Rbck1^em1Ikd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rbck1^em1Ikd
• Name: RanBP-type and C3HC4-type zinc finger containing 1; endonuclease-mediated mutation 1, Fumiyo Ikeda
• MGI ID: MGI:6864280
• Synonyms: Hoil-1l^nzf*, Hoil-1l^{T201A;R208A/T201A;R208A}
• Gene: Rbck1 Location: Chr2:152158254-152174573 bp, - strand Genetic Position: Chr2, 74.83 cM
• Alliance: Rbck1^em1Ikd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/Cas9 technology, T201A;R208A/T201A;R208A nucleotide substitutions in the Npl4 Zinc Finger domain was introduced to mice Rbck1(mutations at the equivalent residues to T203 and R210 in human HOIL-1L). (J:319466)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbck1 Mutation: 43 strains or lines available

References

• Original: J:319466 Gomez-Diaz C, et al., The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains. iScience. 2021 Nov 19;24(11):103241
• All: 1 reference(s)