Kcnj2^tm1Llec
Targeted Allele Detail

Summary

• Symbol: Kcnj2^tm1Llec
• Name: potassium inwardly-rectifying channel, subfamily J, member 2; targeted mutation 1, Lee L Eckhardt
• MGI ID: MGI:6864155
• Synonyms: KCNJ2^R67Q-neo
• Gene: Kcnj2 Location: Chr11:110956990-110967647 bp, + strand Genetic Position: Chr11, 75.23 cM
• Alliance: Kcnj2^tm1Llec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319395
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Nucleotide substitutions
• Mutation details: Using homologous recombination in the ES cells, R67Q mutation found in humans with exertion-induced polymorphic ventricular tachycardia (PMVT), bidirectional ventricular tachycardia (BiVT) and syncope was introduced into the Kcnj2 gene. The target vector contained R67Q-KCNJ2 with a neo cassette inserted into the primary sequence, flanked with loxP sites. (J:319395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj2 Mutation: 30 strains or lines available

References

• Original: J:319395 Reilly L, et al., Genetic Loss of IK1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia. Circ Arrhythm Electrophysiol. 2020 Sep;13(9):e008638
• All: 1 reference(s)