Plod2^tm1.1Kaat
Targeted Allele Detail

Summary

• Symbol: Plod2^tm1.1Kaat
• Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2; targeted mutation 1.1, Atsushi Kasamatsu
• MGI ID: MGI:6863914
• Synonyms: LH2^F
• Gene: Plod2 Location: Chr9:92424276-92490481 bp, + strand Genetic Position: Chr9, 48.4 cM
• Alliance: Plod2^tm1.1Kaat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:318894
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using a BAC clone from the C57BL/6J, the Plod2 gene was targeted to insert a loxP site upstream of exon 2 and FRT flanked neo-selection cassette and second loxP site after exon2. The neo-selection cassette was removed by crossing with Flp recombinase expressing mice, leaving the exon 2 flanked by loxP sites. (J:318894)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plod2 Mutation: 47 strains or lines available

References

• Original: J:318894 Nozaki R, et al., Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration. Biochem Biophys Res Commun. 2022 Jan 8;587:146-152
• All: 1 reference(s)