Mirc53^tm1.1Hmgu
Targeted Allele Detail

Summary

• Symbol: Mirc53^tm1.1Hmgu
• Name: microRNA cluster 53, including Mir221 and Mir222; targeted mutation 1.1, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6863895
• Synonyms: Mir221/222^flox
• Gene: Mirc53 Location: unknown Genetic Position: ChrX, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:318753
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of Mir222 a loxP site and downstream of Mir221 an FRT-flanked neomycin resistance cassette with a 3 prime loxP site. Flp-mediated recombination removed the selection cassette and left the microRNAs flanked. (J:318753)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc53 Mutation: 1 strain or line available

References

• Original: J:318753 Yamaguchi S, et al., Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4. Front Endocrinol (Lausanne). 2021;12:750261
• All: 3 reference(s)