Lgr6^em1Jleh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lgr6^em1Jleh
• Name: leucine-rich repeat-containing G protein-coupled receptor 6; endonuclease-mediated mutation 1, Jessica A Lechoczky
• MGI ID: MGI:6863874
• Synonyms: Lgr6-KO
• Gene: Lgr6 Location: Chr1:134911039-135033014 bp, - strand Genetic Position: Chr1, 58.24 cM
• Alliance: Lgr6^em1Jleh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using the dual guide CRISPR-Cas9 genome modification strategy the Lgr6, the deletion of exons 15 and 16 of the Lgr6 gene resulted in a frameshift and a nonsense transcript. (J:318857)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgr6 Mutation: 85 strains or lines available

References

• Original: J:318857 Khedgikar V, et al., Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use. Bone. 2022 Feb;155:116267
• All: 1 reference(s)