Thbs1^tm1.1Boliu
Targeted Allele Detail

Summary

• Symbol: Thbs1^tm1.1Boliu
• Name: thrombospondin 1; targeted mutation 1.1, Bo Liu
• MGI ID: MGI:6860625
• Synonyms: Thbs1^flox
• Gene: Thbs1 Location: Chr2:117942357-117957614 bp, + strand Genetic Position: Chr2, 59.34 cM, cytoband F1-F3
• Alliance: Thbs1^tm1.1Boliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:318633
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The allele was generated by inserting 2 loxP sites downstream of exon 3 and exon 7 of the Thbs1 gene, respectively. An FRT (flippase recognition target) site flanked neomycin positive selection cassette was also included right before the 3-loxP site. After homologous recombination in SV129-derived ES cells, the neomycin cassette was removed prior to injection of recombinant cells into C57BL/6 blastocysts. (J:318633)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbs1 Mutation: 71 strains or lines available

References

• Original: J:318633 Yang H, et al., Myeloid-Derived TSP1 (Thrombospondin-1) Contributes to Abdominal Aortic Aneurysm Through Suppressing Tissue Inhibitor of Metalloproteinases-1. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):e350-e366
• All: 3 reference(s)