Prrt2^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Prrt2^tm1.1Smoc
• Name: proline-rich transmembrane protein 2; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:6858082
• Synonyms: Prrt2^loxP
• Gene: Prrt2 Location: Chr7:126616703-126620383 bp, - strand Genetic Position: Chr7, 69.28 cM
• Alliance: Prrt2^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255335
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted upstream of exon 2 and was removed via flp-mediated recombination leaving exon 2 floxed. (J:255335)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prrt2 Mutation: 19 strains or lines available

References

• Original: J:255335 Tan GH, et al., PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Cell Res. 2018 Jan;28(1):90-110
• All: 3 reference(s)