Rbbp8^tm1.2Rjbr
Targeted Allele Detail

Summary

• Symbol: Rbbp8^tm1.2Rjbr
• Name: retinoblastoma binding protein 8, endonuclease; targeted mutation 1.2, Richard J Baer
• MGI ID: MGI:6858078
• Synonyms: Ctip^co-rec
• Gene: Rbbp8 Location: Chr18:11766333-11876264 bp, + strand Genetic Position: Chr18, 5.85 cM
• Alliance: Rbbp8^tm1.2Rjbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252618
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 2. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 2 floxed. Cre-mediated recombination removed exon 2. (J:252618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbbp8 Mutation: 51 strains or lines available

References

• Original: J:252618 Reczek CR, et al., The DNA resection protein CtIP promotes mammary tumorigenesis. Oncotarget. 2016 May 31;7(22):32172-83
• All: 2 reference(s)